Indonesian bio diversities, herbal plants as effective functional foods
|Indonesian bio diversities, herbal plants as effective functional foods
Convention on Herbal Medicine in Indonesia
|Materials & Methods and Results
1 Noni juice (Morinda citrifolia)
We have been unveiling the effectiveness of Indonesia noni juice since 2000 and found many functions including actions of anti-bacteria, anti-DNA injury, anti-mutagenicity, anti-hypertension, anti-platelet aggregation, blood fluidity improvement, anti-reactive oxygen species etc.
Recently we found longevity action of Indonesian noni juice using Spontaneous Hypertension Stroke Prone Rats (SHRSP). SHRSP rats develops hypertension following by haemorrhage and or infarction in the brain at rate of almost 100% resulting in death.
100% pure freshly squeezed noni juice from matured fruits was added to 0.1% sodium chloride tap water at 10% and given to 6 week-old male SHRSP rats ad libitum and the control rats were provided 0.1% NaCl water only (each group, n=10).
As shown in Figure, Noni juice group survived longer than the control. Mean survival days of the control and Noni juice groups were 77 days and 107 days, respectively. Statistical significance was observed.
2 Extra virgin coconut oil (EVCO) (Cocos nucifera)
EVCO comprises of more than 60 % medium chain fatty acids and 90% saturated fatty acids, but no trans fatty acids. Because of these compositions, EVCO is highly expected to prevent atheromatous arteriosclerosis resulting in chronic blood vessel associated diseases, obesity, allergies, breast cancer, diabetes mellitus and so on.
We examined the effect on longevity in SHRSP rats. Indonesian made EVCO was mixed with diet at 10% concentration. As a control, Shortening marketing in Japan was given in the same fashion as EVCO group.
As shown in Figure, the animals given Shortening developed earlier death than that provided by EVCO. Mean survival days of Shortening and EVCO groups were 89 days and 104 days, respectively. The difference revealed statistically significant.
Our result can promise the patients with stroke and/or blood disease the longevity.
3 Buah Merah (Pandanus conoideus)
Buah Merah is grown exclusively in Papua island and its extracted oil has been utilized by native tribes for tens thousands years.
We presented the data on in vitro anti-cancer potential at PATPI in 2007 and entire profile of Buah Merah is presented in our books published in Indonesia and Japan.
Today, we show one anti-cancer effect of BM using human non-small cancer cells, A549 in BALB/C nude mice.
A549 tumor mass was subcutaneously implanted and from Day 14 till Day 60, 0.5mL of BM per animal was orally given. The tumor volumes were measured periodically. At Day 61, all the mice were sacrificed and tumor weights were measured.
As shown in Figue, compared to the control, tumor mass of BM treated group was smaller in volume and there was significant difference in the tumor mass of Day 55. From the average tumor weights at Day 61, the inhibition percentage on tumor proliferation by BM treatment was 43.6%, though there was no significance.
We are sure that Indonesia is one of rich countries in terms of biodiversities, especially tropical medicinal plants. Some of them have been utilized as Jamu, but many remain undeveloped.
Needless to say, our bio-diverse species may tremendously help our people to provide benefits and welfare if they could be successfully developed as functional foods or alternative medicines, in order to materialize self-medication or preventive medicine.
The tasks for research and development of our indigenous sources, it takes time, costs a lot, and requires reputable manpower and organized R/D system.